Convergent genetic and expression data implicate immunity in Alzheimer's disease
Identifieur interne : 003660 ( Main/Exploration ); précédent : 003659; suivant : 003661Convergent genetic and expression data implicate immunity in Alzheimer's disease
Auteurs : Lesley Jones [Royaume-Uni] ; Jean-Charles Lambert [France] ; Li-San Wang [États-Unis] ; Seung-Hoan Choi [États-Unis] ; Denise Harold [Royaume-Uni] ; Alexey Vedernikov [Royaume-Uni] ; Valentina Escott-Price [Royaume-Uni] ; Timothy Stone [Royaume-Uni] ; Alexander Richards [Royaume-Uni] ; Céline Bellenguez [France] ; Carla A. Ibrahim-Verbaas [Pays-Bas] ; Adam C. Naj [États-Unis] ; Rebecca Sims [Royaume-Uni] ; Amy Gerrish [Royaume-Uni] ; Gyungah Jun [États-Unis] ; Anita L. Destefano [États-Unis] ; Joshua C. Bis [États-Unis] ; Gary W. Beecham [États-Unis] ; Benjamin Grenier-Boley [France] ; Giancarlo Russo [Suisse] ; Tricia A. Thornton-Wells [États-Unis] ; Nicola Jones [Royaume-Uni] ; Albert V. Smith [Islande] ; Vincent Chouraki [France] ; Charlene Thomas [Royaume-Uni] ; M Arfan Ikram [Pays-Bas] ; Diana Zelenika [France] ; Badri N. Vardarajan [États-Unis] ; Yoichiro Kamatani [France] ; Chiao-Feng Lin [États-Unis] ; Helena Schmidt [Autriche] ; Brian Kunkle [États-Unis] ; Melanie L. Dunstan [Royaume-Uni] ; Agustin Ruiz [Espagne] ; Marie-Thérèse Bihoreau [France] ; Christiane Reitz [États-Unis] ; Florence Pasquier [France] ; Paul Hollingworth [Royaume-Uni] ; Olivier Hanon [France] ; Annette L. Fitzpatrick [États-Unis] ; Joseph D. Buxbaum [États-Unis] ; Dominique Campion [France] ; Paul K. Crane [États-Unis] ; Tim Becker [Allemagne] ; Vilmundur Gudnason [Islande] ; Carlos Cruchaga [États-Unis] ; David Craig [Royaume-Uni] ; Najaf Amin ; Claudine Berr [France] ; Oscar L. Lopez [États-Unis] ; Philip L. De Jager [États-Unis] ; Vincent Deramecourt [France] ; Janet A. Johnston [Royaume-Uni] ; Denis Evans [États-Unis] ; Simon Lovestone [Royaume-Uni] ; Luc Letteneur [France] ; Johanes Kornhuber [Allemagne] ; Lluís Tárraga [Espagne] ; David C. Rubinsztein [Royaume-Uni] ; Gudny Eiriksdottir [Islande] ; Kristel Sleegers [Belgique] ; Alison M. Goate [États-Unis] ; Nathalie Fiévet [France] ; Matthew J. Huentelman [États-Unis] ; Michael Gill [Irlande (pays)] ; Valur Emilsson [Islande] ; Kristelle Brown [Royaume-Uni] ; M Ilyas Kamboh [États-Unis] ; Lina Keller [Suède] ; Pascale Barberger-Gateau [France] ; Bernadette Mcguinness [Royaume-Uni] ; Eric B. Larson [États-Unis] ; Amanda J. Myers [États-Unis] ; Carole Dufouil [France] ; Stephen Todd [Royaume-Uni] ; David Wallon [France] ; Seth Love [Royaume-Uni] ; Pat Kehoe [Royaume-Uni] ; Ekaterina Rogaeva [Canada] ; John Gallacher ; Peter St George-Hyslop [Canada, Royaume-Uni] ; Jordi Clarimon [Espagne] ; Alberti Lle [Espagne] ; Anthony Bayer ; Debby W. Tsuang [États-Unis] ; Lei Yu [États-Unis] ; Magda Tsolaki [Grèce] ; Paola Bossù [Italie] ; Gianfranco Spalletta [Italie] ; Petra Proitsi [Royaume-Uni] ; John Collinge [Royaume-Uni] ; Sandro Sorbi [Italie] ; Florentino Sanchez Garcia [Espagne] ; Nick Fox [Royaume-Uni] ; John Hardy [Royaume-Uni] ; Maria Candida Deniz Naranjo [Espagne] ; Cristina Razquin [Espagne] ; Paola Bosco [Italie] ; Robert Clarke [Royaume-Uni] ; Carol Brayne [Royaume-Uni] ; Daniela Galimberti [Italie] ; Michelangelo Mancuso [Italie] ; Susanne Moebus [Allemagne] ; Patrizia Mecocci [Italie] ; Maria Del Zompo [Italie] ; Wolfgang Maier [Allemagne] ; Harald Hampel ; Alberto Pilotto [Italie] ; Maria Bullido [Espagne] ; Francesco Panza [Italie] ; Paolo Caffarra [Italie] ; Benedetta Nacmias [Italie] ; John R. Gilbert [États-Unis] ; Manuel Mayhaus ; Frank Jessen [Allemagne] ; Martin Dichgans [Allemagne] ; Lars Lannfelt [Suède] ; Hakon Hakonarson [États-Unis] ; Sabrina Pichler ; Minerva M. Carrasquillo ; Martin Ingelsson [Suède] ; Duane Beekly [États-Unis] ; Victoria Alavarez [Espagne] ; Fanggeng Zou ; Otto Valladares [États-Unis] ; Steven G. Younkin ; Eliecer Coto [Espagne] ; Kara L. Hamilton-Nelson [États-Unis] ; Ignacio Mateo [Espagne] ; Michael J. Owen [Royaume-Uni] ; Kelley M. Faber [États-Unis] ; Palmi V. Jonsson [Islande] ; Onofre Combarros [Espagne] ; Michael C. O'Donovan [Royaume-Uni] ; Laura B. Cantwell [États-Unis] ; Hilkka Soininen [Finlande] ; Deborah Blacker [États-Unis] ; Simon Mead [Royaume-Uni] ; Thomas H. Mosley [États-Unis] ; David A. Bennett [États-Unis] ; Tamara B. Harris [États-Unis] ; Laura Fratiglioni [Suède] ; Clive Holmes [Royaume-Uni] ; Renee Fag De Bruijn [Pays-Bas] ; Peter Passmore [Royaume-Uni] ; Thomas J. Montine [États-Unis] ; Karolien Bettens [Belgique] ; Jerome I. Rotter [États-Unis] ; Alexis Brice [France] ; Kevin Morgan [Royaume-Uni] ; Tatiana M. Foroud [États-Unis] ; Walter A. Kukull [États-Unis] ; Didier Hannequin [France] ; John F. Powell [Royaume-Uni] ; Michael A. Nalls [États-Unis] ; Karen Ritchie [France] ; Kathryn L. Lunetta [États-Unis] ; John Sk Kauwe [Royaume-Uni] ; Eric Boerwinkle [États-Unis] ; Matthias Riemenschneider ; Mercè Boada [Espagne] ; Mikko Hiltunen [Finlande] ; Eden R. Martin [États-Unis] ; Pau Pastor [Espagne] ; Reinhold Schmidt [Autriche] ; Dan Rujescu [Allemagne] ; Jean-François Dartigues [France] ; Richard Mayeux [États-Unis] ; Christophe Tzourio [France] ; Albert Hofman [Pays-Bas] ; Markus M. Nöthen [Allemagne] ; Caroline Graff [Suède] ; Bruce M. Psaty [États-Unis] ; Jonathan L. Haines [États-Unis] ; Mark Lathrop [France, Canada] ; Margaret A. Pericak-Vance [États-Unis] ; Lenore J. Launer [États-Unis] ; Lindsay A. Farrer [États-Unis] ; Cornelia M. Van Duijn ; Christine Van Broekhoven [Belgique] ; Alfredo Ramirez [Allemagne] ; Gerard D. Schellenberg [États-Unis] ; Sudha Seshadri [États-Unis] ; Philippe Amouyel [France] ; Julie Williams [Royaume-Uni] ; Peter A. Holmans [Royaume-Uni]Source :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5260 ] ; 2014.
Abstract
Late–onset Alzheimer's disease (AD) is heritable with 20 genes showing genome wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease we extended these genetic data in a pathway analysis.
The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain.
ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (p = 3.27×10-12 after multiple testing correction for pathways), regulation of endocytosis (p = 1.31×10-11), cholesterol transport (p = 2.96 × 10-9) and proteasome-ubiquitin activity (p = 1.34×10-6). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected p 0.002 – 0.05).
The immune response, regulation of endocytosis, cholesterol transport and protein ubiquitination represent prime targets for AD therapeutics.
Url:
DOI: 10.1016/j.jalz.2014.05.1757
PubMed: 25533204
PubMed Central: 4672734
Affiliations:
- Allemagne, Autriche, Belgique, Canada, Espagne, Finlande, France, Grèce, Irlande (pays), Islande, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Aquitaine, Arizona, Bavière, Californie, Catalogne, Communauté de Madrid, District de Cologne, District de Haute-Bavière, East Middle Sweden, Floride, Grand Londres, Haute-Normandie, Hauts-de-France, Hollande-Méridionale, Illinois, Indiana, Languedoc-Roussillon, Latium, Lombardie, Maryland, Massachusetts, Missouri (État), Nord-Pas-de-Calais, Nottinghamshire, Nouvelle-Aquitaine, Occitanie (région administrative), Ontario, Oxfordshire, Pennsylvanie, Province d'Anvers, Québec, Rhénanie-du-Nord-Westphalie, Région Normandie, Région flamande, Svealand, Tennessee, Texas, Toscane, Washington (État), État de New York, Île-de-France
- Anvers, Barcelone, Bonn, Bordeaux, Cambridge, Leyde, Lille, Londres, Madrid, Milan, Montpellier, Montréal, Munich, Nottingham, Oxford, Paris, Pise, Pittsburgh, Rome, Rouen, Saint-Louis (Missouri), Seattle, Stockholm, Toronto, Uppsala, Évry (Essonne)
- Université Lille 2, Université Louis-et-Maximilien de Munich, Université Paris-Descartes, Université autonome de Barcelone, Université d'Anvers, Université d'Oxford, Université d'Uppsala, Université de Cambridge, Université de Nottingham, Université de Pise, Université de Pittsburgh, Université de Toronto, Université de Washington, École de médecine (Université Washington de Saint-Louis)
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USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation></author><author><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Vedernikov, Alexey" sort="Vedernikov, Alexey" uniqKey="Vedernikov A" first="Alexey" last="Vedernikov">Alexey 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Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="3"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A" last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Epidemiology, Clinical Genetics and Neurology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Clinical Genetics and Neurology, Erasmus MC University Medical Center, Rotterdam, 3015 CE</wicri:regionArea><wicri:noRegion>3015 CE</wicri:noRegion></affiliation></author><author><name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C" last="Naj">Adam C. Naj</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Gerrish, Amy" sort="Gerrish, Amy" uniqKey="Gerrish A" first="Amy" last="Gerrish">Amy Gerrish</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218</wicri:regionArea><wicri:noRegion>02218</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA, 02215</wicri:regionArea><wicri:noRegion>02215</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation wicri:level="4"><nlm:aff id="A10">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><affiliation wicri:level="3"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation></author><author><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name><affiliation wicri:level="1"><nlm:aff id="A12">Functional Genomics Center, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Functional Genomics Center, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Thornton Wells, Tricia A" sort="Thornton Wells, Tricia A" uniqKey="Thornton Wells T" first="Tricia A" last="Thornton-Wells">Tricia A. Thornton-Wells</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212</wicri:regionArea><wicri:noRegion>37212</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Nicola" sort="Jones, Nicola" uniqKey="Jones N" first="Nicola" last="Jones">Nicola Jones</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="3"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation></author><author><name sortKey="Thomas, Charlene" sort="Thomas, Charlene" uniqKey="Thomas C" first="Charlene" last="Thomas">Charlene Thomas</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation wicri:level="1"><nlm:aff id="A16">Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE</wicri:regionArea><wicri:noRegion>3015 CE</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A17">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation wicri:level="3"><nlm:aff id="A18">Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N" last="Vardarajan">Badri N. Vardarajan</name><affiliation wicri:level="1"><nlm:aff id="A23">Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation></author><author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><affiliation wicri:level="3"><nlm:aff id="A19">Fondation Jean Dausset- CEPH, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lin, Chiao Feng" sort="Lin, Chiao Feng" uniqKey="Lin C" first="Chiao-Feng" last="Lin">Chiao-Feng Lin</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A21">Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, 8010, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, 8010</wicri:regionArea><wicri:noRegion>8010</wicri:noRegion></affiliation></author><author><name sortKey="Kunkle, Brian" sort="Kunkle, Brian" uniqKey="Kunkle B" first="Brian" last="Kunkle">Brian Kunkle</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation wicri:level="1"><nlm:aff id="A22">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029</wicri:regionArea><wicri:noRegion>8029</wicri:noRegion></affiliation></author><author><name sortKey="Bihoreau, Marie Therese" sort="Bihoreau, Marie Therese" uniqKey="Bihoreau M" first="Marie-Thérèse" last="Bihoreau">Marie-Thérèse Bihoreau</name><affiliation wicri:level="3"><nlm:aff id="A18">Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><affiliation wicri:level="1"><nlm:aff id="A23">Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><orgName type="university">Université Lille 2</orgName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation></author><author><name sortKey="Hollingworth, Paul" sort="Hollingworth, Paul" uniqKey="Hollingworth P" first="Paul" last="Hollingworth">Paul Hollingworth</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation wicri:level="4"><nlm:aff id="A27">UMR 894 Inserm, Faculté de Médecine, Université Paris Descartes, Paris, 75014, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 894 Inserm, Faculté de Médecine, Université Paris Descartes, Paris, 75014</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L" last="Fitzpatrick">Annette L. Fitzpatrick</name><affiliation wicri:level="4"><nlm:aff id="A10">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A28">Departments of Epidemiology and Global Health, University of Washington, Seattle, WA 98101, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Epidemiology and Global Health, University of Washington, Seattle, WA 98101</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D" last="Buxbaum">Joseph D. Buxbaum</name><affiliation wicri:level="2"><nlm:aff id="A29">Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A30">Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A31">Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="3"><nlm:aff id="A32">INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K" last="Crane">Paul K. Crane</name><affiliation wicri:level="4"><nlm:aff id="A33">Department of Medicine, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><affiliation wicri:level="3"><nlm:aff id="A34">German Center for Neurodegenerative Diseases (DZNE, Bonn) and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE, Bonn) and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><affiliation wicri:level="4"><nlm:aff id="A35">Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO 98122, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO 98122</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A37">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE the Netherlands</nlm:aff><wicri:noCountry code="subfield">3015 CE the Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="3"><nlm:aff id="A38">INSERM U888, Hôpital La Colombière, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U888, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><affiliation wicri:level="2"><nlm:aff id="A39">Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L" last="De Jager">Philip L. De Jager</name><affiliation wicri:level="2"><nlm:aff id="A40">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A41">Program in Medical and Population Genetics, Broad Institute, Boston, MA 02215 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics, Broad Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><affiliation wicri:level="1"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation></author><author><name sortKey="Johnston, Janet A" sort="Johnston, Janet A" uniqKey="Johnston J" first="Janet A" last="Johnston">Janet A. Johnston</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><affiliation wicri:level="2"><nlm:aff id="A42">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="3"><nlm:aff id="A43">King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill</wicri:orgArea></affiliation></author><author><name sortKey="Letteneur, Luc" sort="Letteneur, Luc" uniqKey="Letteneur L" first="Luc" last="Letteneur">Luc Letteneur</name><affiliation wicri:level="3"><nlm:aff id="A44">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Kornhuber, Johanes" sort="Kornhuber, Johanes" uniqKey="Kornhuber J" first="Johanes" last="Kornhuber">Johanes Kornhuber</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg</wicri:regionArea><wicri:noRegion>Friedrich-Alexander-University Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Friedrich-Alexander-University Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Friedrich-Alexander-University Erlangen-Nuremberg</wicri:noRegion></affiliation></author><author><name sortKey="Tarraga, Lluis" sort="Tarraga, Lluis" uniqKey="Tarraga L" first="Lluís" last="Tárraga">Lluís Tárraga</name><affiliation wicri:level="1"><nlm:aff id="A22">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029</wicri:regionArea><wicri:noRegion>8029</wicri:noRegion></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name><affiliation wicri:level="4"><nlm:aff id="A46">Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="A15">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation wicri:level="1"><nlm:aff id="A47">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A48">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M" last="Goate">Alison M. Goate</name><affiliation wicri:level="4"><nlm:aff id="A35">Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO 98122, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO 98122</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation wicri:level="3"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation></author><author><name sortKey="Huentelman, Matthew J" sort="Huentelman, Matthew J" uniqKey="Huentelman M" first="Matthew J" last="Huentelman">Matthew J. Huentelman</name><affiliation wicri:level="2"><nlm:aff id="A49">Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation wicri:level="1"><nlm:aff id="A50">Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><affiliation wicri:level="4"><nlm:aff id="A51">Institute of Genetics, Queen's Medical Centre, University of Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics, Queen's Medical Centre, University of Nottingham</wicri:regionArea><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName><orgName type="university">Université de Nottingham</orgName></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><affiliation wicri:level="4"><nlm:aff id="A52">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A53">Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Keller, Lina" sort="Keller, Lina" uniqKey="Keller L" first="Lina" last="Keller">Lina Keller</name><affiliation wicri:level="3"><nlm:aff id="A54">Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><affiliation wicri:level="3"><nlm:aff id="A44">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Mcguinness, Bernadette" sort="Mcguinness, Bernadette" uniqKey="Mcguinness B" first="Bernadette" last="Mcguinness">Bernadette Mcguinness</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><affiliation wicri:level="4"><nlm:aff id="A33">Department of Medicine, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="A55">Group Health Research Institute, Group Health, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Myers, Amanda J" sort="Myers, Amanda J" uniqKey="Myers A" first="Amanda J" last="Myers">Amanda J. Myers</name><affiliation wicri:level="2"><nlm:aff id="A56">Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33124</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="3"><nlm:aff id="A44">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Todd, Stephen" sort="Todd, Stephen" uniqKey="Todd S" first="Stephen" last="Todd">Stephen Todd</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Wallon, David" sort="Wallon, David" uniqKey="Wallon D" first="David" last="Wallon">David Wallon</name><affiliation wicri:level="3"><nlm:aff id="A32">INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><affiliation wicri:level="1"><nlm:aff id="A57">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Kehoe, Pat" sort="Kehoe, Pat" uniqKey="Kehoe P" first="Pat" last="Kehoe">Pat Kehoe</name><affiliation wicri:level="1"><nlm:aff id="A57">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="4"><nlm:aff id="A58">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation><nlm:aff id="A59">Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK</nlm:aff><wicri:noCountry code="subfield">Cardiff UK</wicri:noCountry></affiliation></author><author><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><affiliation wicri:level="4"><nlm:aff id="A58">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A60">Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 1TN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 1TN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation wicri:level="4"><nlm:aff id="A61">Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A62">Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lle, Alberti" sort="Lle, Alberti" uniqKey="Lle A" first="Alberti" last="Lle">Alberti Lle</name><affiliation wicri:level="4"><nlm:aff id="A61">Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A62">Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bayer, Anthony" sort="Bayer, Anthony" uniqKey="Bayer A" first="Anthony" last="Bayer">Anthony Bayer</name><affiliation><nlm:aff id="A59">Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK</nlm:aff><wicri:noCountry code="subfield">Cardiff UK</wicri:noCountry></affiliation></author><author><name sortKey="Tsuang, Debby W" sort="Tsuang, Debby W" uniqKey="Tsuang D" first="Debby W" last="Tsuang">Debby W. Tsuang</name><affiliation wicri:level="4"><nlm:aff id="A63">Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:aff id="A65">Aristotle University of Thessaloniki, Despere 3, Thessaloniki, 54621, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Aristotle University of Thessaloniki, Despere 3, Thessaloniki, 54621</wicri:regionArea><wicri:noRegion>54621</wicri:noRegion></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation wicri:level="3"><nlm:aff id="A66">Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation wicri:level="3"><nlm:aff id="A66">Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Proitsi, Petra" sort="Proitsi, Petra" uniqKey="Proitsi P" first="Petra" last="Proitsi">Petra Proitsi</name><affiliation wicri:level="3"><nlm:aff id="A43">King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill</wicri:orgArea></affiliation></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><affiliation wicri:level="3"><nlm:aff id="A67">MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation wicri:level="1"><nlm:aff id="A68">Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological and Psychiatric Sciences, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Florentino Sanchez" sort="Garcia, Florentino Sanchez" uniqKey="Garcia F" first="Florentino Sanchez" last="Garcia">Florentino Sanchez Garcia</name><affiliation wicri:level="1"><nlm:aff id="A70">Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Nick" sort="Fox, Nick" uniqKey="Fox N" first="Nick" last="Fox">Nick Fox</name><affiliation wicri:level="3"><nlm:aff id="A71">Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="3"><nlm:aff id="A72">Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Naranjo, Maria Candida Deniz" sort="Naranjo, Maria Candida Deniz" uniqKey="Naranjo M" first="Maria Candida Deniz" last="Naranjo">Maria Candida Deniz Naranjo</name><affiliation wicri:level="1"><nlm:aff id="A70">Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author><author><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name><affiliation wicri:level="1"><nlm:aff id="A131">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Bosco, Paola" sort="Bosco, Paola" uniqKey="Bosco P" first="Paola" last="Bosco">Paola Bosco</name><affiliation wicri:level="1"><nlm:aff id="A73">IRCCS Associazione Oasi Maria SS, Troina, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Associazione Oasi Maria SS, Troina</wicri:regionArea><wicri:noRegion>Troina</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="4"><nlm:aff id="A74">Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><affiliation wicri:level="4"><nlm:aff id="A75">Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="3"><nlm:aff id="A76">University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation wicri:level="4"><nlm:aff id="A77">Neurological Clinic, University of Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Clinic, University of Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation wicri:level="1"><nlm:aff id="A78">Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:aff id="A79">Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name><affiliation wicri:level="1"><nlm:aff id="A80">Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation wicri:level="3"><nlm:aff id="A81">Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation><nlm:aff id="A82">Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.)</nlm:aff><wicri:noCountry code="subfield">Germany (H.H.)</wicri:noCountry></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation wicri:level="1"><nlm:aff id="A83">Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG)</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo (FG)</wicri:noRegion></affiliation></author><author><name sortKey="Bullido, Maria" sort="Bullido, Maria" uniqKey="Bullido M" first="Maria" last="Bullido">Maria Bullido</name><affiliation wicri:level="1"><nlm:aff id="A84">Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A85">Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A86">Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation wicri:level="1"><nlm:aff id="A87">Departement of Geriatrics,Center for Aging Brain, University of Bari, Bari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Departement of Geriatrics,Center for Aging Brain, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><affiliation wicri:level="1"><nlm:aff id="A88">Department of Neuroscience-University of Parma, Parma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience-University of Parma, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A89">Center for Cognitive Disorders AUSL, Parma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Cognitive Disorders AUSL, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation wicri:level="1"><nlm:aff id="A68">Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological and Psychiatric Sciences, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Gilbert, John R" sort="Gilbert, John R" uniqKey="Gilbert J" first="John R" last="Gilbert">John R. Gilbert</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A90">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL 33124</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name><affiliation><nlm:aff id="A91">Dept. Of Psychiatry, University Hospital, Saarland</nlm:aff><wicri:noCountry code="subfield">Saarland</wicri:noCountry></affiliation></author><author><name sortKey="Jessen, Frank" sort="Jessen, Frank" uniqKey="Jessen F" first="Frank" last="Jessen">Frank Jessen</name><affiliation wicri:level="3"><nlm:aff id="A81">Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="4"><nlm:aff id="A133">Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany and German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany and German Center for Neurodegenerative Diseases (DZNE, Munich), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation wicri:level="4"><nlm:aff id="A92">Dept. of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Public Health/Geriatrics, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:aff id="A93">Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><affiliation><nlm:aff id="A91">Dept. Of Psychiatry, University Hospital, Saarland</nlm:aff><wicri:noCountry code="subfield">Saarland</wicri:noCountry></affiliation></author><author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M" last="Carrasquillo">Minerva M. Carrasquillo</name><affiliation><nlm:aff id="A94">Department of Neuroscience, Mayo Clinic, Jacksonville Florida 32224</nlm:aff><wicri:noCountry code="subfield">Jacksonville Florida 32224</wicri:noCountry></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation wicri:level="4"><nlm:aff id="A92">Dept. of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Public Health/Geriatrics, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name><affiliation wicri:level="4"><nlm:aff id="A95">National Alzheimer's Coordinating Center, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Alzheimer's Coordinating Center, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Alavarez, Victoria" sort="Alavarez, Victoria" uniqKey="Alavarez V" first="Victoria" last="Alavarez">Victoria Alavarez</name><affiliation wicri:level="1"><nlm:aff id="A96">Genetica molecular-Huca-Oviedo, Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica molecular-Huca-Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Zou, Fanggeng" sort="Zou, Fanggeng" uniqKey="Zou F" first="Fanggeng" last="Zou">Fanggeng Zou</name><affiliation><nlm:aff id="A94">Department of Neuroscience, Mayo Clinic, Jacksonville Florida 32224</nlm:aff><wicri:noCountry code="subfield">Jacksonville Florida 32224</wicri:noCountry></affiliation></author><author><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G" last="Younkin">Steven G. Younkin</name><affiliation><nlm:aff id="A94">Department of Neuroscience, Mayo Clinic, Jacksonville Florida 32224</nlm:aff><wicri:noCountry code="subfield">Jacksonville Florida 32224</wicri:noCountry></affiliation></author><author><name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name><affiliation wicri:level="1"><nlm:aff id="A96">Genetica molecular-Huca-Oviedo, Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica molecular-Huca-Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L" last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation wicri:level="1"><nlm:aff id="A97">Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Faber, Kelley M" sort="Faber, Kelley M" uniqKey="Faber K" first="Kelley M" last="Faber">Kelley M. Faber</name><affiliation wicri:level="2"><nlm:aff id="A98">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V" last="Jonsson">Palmi V. Jonsson</name><affiliation wicri:level="1"><nlm:aff id="A99">Landspitali University Hospital, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Landspitali University Hospital, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation wicri:level="1"><nlm:aff id="A97">Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C" last="O'Donovan">Michael C. O'Donovan</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B" last="Cantwell">Laura B. Cantwell</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="A100">Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, 70211 Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A101">Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio</wicri:regionArea><wicri:noRegion>FIN-70211 Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><affiliation wicri:level="2"><nlm:aff id="A102">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A104">Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><affiliation wicri:level="3"><nlm:aff id="A67">MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation wicri:level="2"><nlm:aff id="A106">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name><affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A106">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation wicri:level="2"><nlm:aff id="A107">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><affiliation wicri:level="3"><nlm:aff id="A108">Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation><nlm:aff id="A109">Dept Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, S-14186 Stockholm</nlm:aff><wicri:noCountry code="subfield">S-14186 Stockholm</wicri:noCountry></affiliation></author><author><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><affiliation wicri:level="1"><nlm:aff id="A110">Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="De Bruijn, Renee Fag" sort="De Bruijn, Renee Fag" uniqKey="De Bruijn R" first="Renee Fag" last="De Bruijn">Renee Fag De Bruijn</name><affiliation wicri:level="1"><nlm:aff id="A111">Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE</wicri:regionArea><wicri:noRegion>3015 CE</wicri:noRegion></affiliation></author><author><name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name><affiliation wicri:level="4"><nlm:aff id="A112">Department of Pathology, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation wicri:level="1"><nlm:aff id="A47">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A48">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:aff id="A113">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:aff id="A114">CRicm-UMRS975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CRicm-UMRS975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A115">AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital de la Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><affiliation wicri:level="4"><nlm:aff id="A51">Institute of Genetics, Queen's Medical Centre, University of Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics, Queen's Medical Centre, University of Nottingham</wicri:regionArea><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName><orgName type="university">Université de Nottingham</orgName></affiliation></author><author><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M" last="Foroud">Tatiana M. Foroud</name><affiliation wicri:level="2"><nlm:aff id="A98">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name><affiliation wicri:level="4"><nlm:aff id="A116">Department of Epidemiology, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="3"><nlm:aff id="A32">INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name><affiliation wicri:level="3"><nlm:aff id="A43">King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill</wicri:orgArea></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><affiliation wicri:level="2"><nlm:aff id="A117">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><nlm:aff id="A38">INSERM U888, Hôpital La Colombière, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U888, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation></author><author><name sortKey="Kauwe, John Sk" sort="Kauwe, John Sk" uniqKey="Kauwe J" first="John Sk" last="Kauwe">John Sk Kauwe</name><affiliation wicri:level="4"><nlm:aff id="A46">Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="2"><nlm:aff id="A118">Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A119">Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><affiliation><nlm:aff id="A120">Department of Psychiatry, University Hospital, Saarland</nlm:aff><wicri:noCountry code="subfield">Saarland</wicri:noCountry></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><affiliation wicri:level="1"><nlm:aff id="A22">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029</wicri:regionArea><wicri:noRegion>8029</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A121">Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona 8029, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona 8029</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation wicri:level="1"><nlm:aff id="A100">Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, 70211 Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A101">Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio</wicri:regionArea><wicri:noRegion>FIN-70211 Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><affiliation wicri:level="1"><nlm:aff id="A132">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research and Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research and Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</wicri:regionArea><wicri:noRegion>Instituto de Salud Carlos III</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A122">Department of Neurology, Medical University of Graz, Graz 8010, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Graz, Graz 8010</wicri:regionArea><wicri:noRegion>Graz 8010</wicri:noRegion></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation wicri:level="4"><nlm:aff id="A123">Department of Psychiatry, University of Munich, Munich and University of Halle, Halle, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Munich, Munich and University of Halle, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation wicri:level="3"><nlm:aff id="A44">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A124">Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><affiliation wicri:level="1"><nlm:aff id="A23">Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:aff id="A125">Inserm U708, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U708, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><wicri:noRegion>33076, Bordeaux</wicri:noRegion><wicri:noRegion>33076, Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="A16">Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE</wicri:regionArea><wicri:noRegion>3015 CE</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A17">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation wicri:level="3"><nlm:aff id="A126">Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><affiliation wicri:level="1"><nlm:aff id="A127">Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, KIADRC, Novum floor 5, S14186 Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, KIADRC, Novum floor 5, S14186 Stockholm</wicri:regionArea><wicri:noRegion>S14186 Stockholm</wicri:noRegion></affiliation><affiliation><nlm:aff id="A109">Dept Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, S-14186 Stockholm</nlm:aff><wicri:noCountry code="subfield">S-14186 Stockholm</wicri:noCountry></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><nlm:aff id="A10">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212</wicri:regionArea><wicri:noRegion>37212</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A128">Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="3"><nlm:aff id="A18">Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A19">Fondation Jean Dausset- CEPH, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A129">McGill University and Génome Québec Innovation Centre, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University and Génome Québec Innovation Centre, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:aff id="A107">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218</wicri:regionArea><wicri:noRegion>02218</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA, 02215</wicri:regionArea><wicri:noRegion>02215</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A103">Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A130">Department of Neurology, Boston University School of Medicine, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A37">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE the Netherlands</nlm:aff><wicri:noCountry code="subfield">3015 CE the Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Van Broekhoven, Christine" sort="Van Broekhoven, Christine" uniqKey="Van Broekhoven C" first="Christine" last="Van Broekhoven">Christine Van Broekhoven</name><affiliation wicri:level="1"><nlm:aff id="A47">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A48">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name><affiliation wicri:level="3"><nlm:aff id="A26">Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D" last="Schellenberg">Gerard D. Schellenberg</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="A130">Department of Neurology, Boston University School of Medicine, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation></author><author><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Holmans, Peter A" sort="Holmans, Peter A" uniqKey="Holmans P" first="Peter A" last="Holmans">Peter A. Holmans</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25533204</idno><idno type="pmc">4672734</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672734</idno><idno type="RBID">PMC:4672734</idno><idno type="doi">10.1016/j.jalz.2014.05.1757</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001082</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001082</idno><idno type="wicri:Area/Pmc/Curation">001057</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001057</idno><idno type="wicri:Area/Pmc/Checkpoint">001778</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001778</idno><idno type="wicri:Area/Ncbi/Merge">004547</idno><idno type="wicri:Area/Ncbi/Curation">004547</idno><idno type="wicri:Area/Ncbi/Checkpoint">004547</idno><idno type="wicri:doubleKey">1552-5260:2014:Jones L:convergent:genetic:and</idno><idno type="wicri:Area/Main/Merge">003833</idno><idno type="wicri:Area/Main/Curation">003660</idno><idno type="wicri:Area/Main/Exploration">003660</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Convergent genetic and expression data implicate immunity in Alzheimer's disease</title><author><name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><orgName type="university">Université Lille 2</orgName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation></author><author><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Vedernikov, Alexey" sort="Vedernikov, Alexey" uniqKey="Vedernikov A" first="Alexey" last="Vedernikov">Alexey Vedernikov</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Stone, Timothy" sort="Stone, Timothy" uniqKey="Stone T" first="Timothy" last="Stone">Timothy Stone</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Richards, Alexander" sort="Richards, Alexander" uniqKey="Richards A" first="Alexander" last="Richards">Alexander Richards</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="1"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><orgName type="university">Université Lille 2</orgName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A" last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Epidemiology, Clinical Genetics and Neurology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Clinical Genetics and Neurology, Erasmus MC University Medical Center, Rotterdam, 3015 CE</wicri:regionArea><wicri:noRegion>3015 CE</wicri:noRegion></affiliation></author><author><name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C" last="Naj">Adam C. Naj</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Gerrish, Amy" sort="Gerrish, Amy" uniqKey="Gerrish A" first="Amy" last="Gerrish">Amy Gerrish</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218</wicri:regionArea><wicri:noRegion>02218</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA, 02215</wicri:regionArea><wicri:noRegion>02215</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation wicri:level="4"><nlm:aff id="A10">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><affiliation wicri:level="1"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><orgName type="university">Université Lille 2</orgName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation></author><author><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name><affiliation wicri:level="1"><nlm:aff id="A12">Functional Genomics Center, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Functional Genomics Center, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Thornton Wells, Tricia A" sort="Thornton Wells, Tricia A" uniqKey="Thornton Wells T" first="Tricia A" last="Thornton-Wells">Tricia A. Thornton-Wells</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212</wicri:regionArea><wicri:noRegion>37212</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Nicola" sort="Jones, Nicola" uniqKey="Jones N" first="Nicola" last="Jones">Nicola Jones</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><orgName type="university">Université Lille 2</orgName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Charlene" sort="Thomas, Charlene" uniqKey="Thomas C" first="Charlene" last="Thomas">Charlene Thomas</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation wicri:level="1"><nlm:aff id="A16">Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE</wicri:regionArea><wicri:noRegion>3015 CE</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A17">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation wicri:level="3"><nlm:aff id="A18">Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N" last="Vardarajan">Badri N. Vardarajan</name><affiliation wicri:level="1"><nlm:aff id="A23">Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation></author><author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><affiliation wicri:level="3"><nlm:aff id="A19">Fondation Jean Dausset- CEPH, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lin, Chiao Feng" sort="Lin, Chiao Feng" uniqKey="Lin C" first="Chiao-Feng" last="Lin">Chiao-Feng Lin</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A21">Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, 8010, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, 8010</wicri:regionArea><wicri:noRegion>8010</wicri:noRegion></affiliation></author><author><name sortKey="Kunkle, Brian" sort="Kunkle, Brian" uniqKey="Kunkle B" first="Brian" last="Kunkle">Brian Kunkle</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation wicri:level="1"><nlm:aff id="A22">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029</wicri:regionArea><wicri:noRegion>8029</wicri:noRegion></affiliation></author><author><name sortKey="Bihoreau, Marie Therese" sort="Bihoreau, Marie Therese" uniqKey="Bihoreau M" first="Marie-Thérèse" last="Bihoreau">Marie-Thérèse Bihoreau</name><affiliation wicri:level="3"><nlm:aff id="A18">Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><affiliation wicri:level="1"><nlm:aff id="A23">Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><orgName type="university">Université Lille 2</orgName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation></author><author><name sortKey="Hollingworth, Paul" sort="Hollingworth, Paul" uniqKey="Hollingworth P" first="Paul" last="Hollingworth">Paul Hollingworth</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation wicri:level="4"><nlm:aff id="A27">UMR 894 Inserm, Faculté de Médecine, Université Paris Descartes, Paris, 75014, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 894 Inserm, Faculté de Médecine, Université Paris Descartes, Paris, 75014</wicri:regionArea><wicri:noRegion>75014</wicri:noRegion><orgName type="university">Université Paris-Descartes</orgName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L" last="Fitzpatrick">Annette L. Fitzpatrick</name><affiliation wicri:level="4"><nlm:aff id="A10">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A28">Departments of Epidemiology and Global Health, University of Washington, Seattle, WA 98101, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Epidemiology and Global Health, University of Washington, Seattle, WA 98101</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D" last="Buxbaum">Joseph D. Buxbaum</name><affiliation wicri:level="2"><nlm:aff id="A29">Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A30">Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A31">Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="3"><nlm:aff id="A32">INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K" last="Crane">Paul K. Crane</name><affiliation wicri:level="4"><nlm:aff id="A33">Department of Medicine, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><affiliation wicri:level="3"><nlm:aff id="A34">German Center for Neurodegenerative Diseases (DZNE, Bonn) and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE, Bonn) and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><affiliation wicri:level="4"><nlm:aff id="A35">Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO 98122, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO 98122</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A37">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE the Netherlands</nlm:aff><wicri:noCountry code="subfield">3015 CE the Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="3"><nlm:aff id="A38">INSERM U888, Hôpital La Colombière, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U888, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><affiliation wicri:level="2"><nlm:aff id="A39">Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L" last="De Jager">Philip L. De Jager</name><affiliation wicri:level="2"><nlm:aff id="A40">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A41">Program in Medical and Population Genetics, Broad Institute, Boston, MA 02215 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics, Broad Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><affiliation wicri:level="1"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation></author><author><name sortKey="Johnston, Janet A" sort="Johnston, Janet A" uniqKey="Johnston J" first="Janet A" last="Johnston">Janet A. Johnston</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><affiliation wicri:level="2"><nlm:aff id="A42">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="3"><nlm:aff id="A43">King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill</wicri:orgArea></affiliation></author><author><name sortKey="Letteneur, Luc" sort="Letteneur, Luc" uniqKey="Letteneur L" first="Luc" last="Letteneur">Luc Letteneur</name><affiliation wicri:level="3"><nlm:aff id="A44">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Kornhuber, Johanes" sort="Kornhuber, Johanes" uniqKey="Kornhuber J" first="Johanes" last="Kornhuber">Johanes Kornhuber</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg</wicri:regionArea><wicri:noRegion>Friedrich-Alexander-University Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Friedrich-Alexander-University Erlangen-Nuremberg</wicri:noRegion><wicri:noRegion>Friedrich-Alexander-University Erlangen-Nuremberg</wicri:noRegion></affiliation></author><author><name sortKey="Tarraga, Lluis" sort="Tarraga, Lluis" uniqKey="Tarraga L" first="Lluís" last="Tárraga">Lluís Tárraga</name><affiliation wicri:level="1"><nlm:aff id="A22">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029</wicri:regionArea><wicri:noRegion>8029</wicri:noRegion></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name><affiliation wicri:level="4"><nlm:aff id="A46">Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="A15">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation wicri:level="1"><nlm:aff id="A47">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A48">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M" last="Goate">Alison M. Goate</name><affiliation wicri:level="4"><nlm:aff id="A35">Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO 98122, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO 98122</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation wicri:level="1"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><wicri:noRegion>59000</wicri:noRegion></affiliation></author><author><name sortKey="Huentelman, Matthew J" sort="Huentelman, Matthew J" uniqKey="Huentelman M" first="Matthew J" last="Huentelman">Matthew J. Huentelman</name><affiliation wicri:level="2"><nlm:aff id="A49">Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation wicri:level="1"><nlm:aff id="A50">Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><affiliation wicri:level="4"><nlm:aff id="A51">Institute of Genetics, Queen's Medical Centre, University of Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics, Queen's Medical Centre, University of Nottingham</wicri:regionArea><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName><orgName type="university">Université de Nottingham</orgName></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><affiliation wicri:level="4"><nlm:aff id="A52">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A53">Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Keller, Lina" sort="Keller, Lina" uniqKey="Keller L" first="Lina" last="Keller">Lina Keller</name><affiliation wicri:level="3"><nlm:aff id="A54">Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><affiliation wicri:level="3"><nlm:aff id="A44">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Mcguinness, Bernadette" sort="Mcguinness, Bernadette" uniqKey="Mcguinness B" first="Bernadette" last="Mcguinness">Bernadette Mcguinness</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><affiliation wicri:level="4"><nlm:aff id="A33">Department of Medicine, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="A55">Group Health Research Institute, Group Health, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Myers, Amanda J" sort="Myers, Amanda J" uniqKey="Myers A" first="Amanda J" last="Myers">Amanda J. Myers</name><affiliation wicri:level="2"><nlm:aff id="A56">Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33124</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="3"><nlm:aff id="A44">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Todd, Stephen" sort="Todd, Stephen" uniqKey="Todd S" first="Stephen" last="Todd">Stephen Todd</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Wallon, David" sort="Wallon, David" uniqKey="Wallon D" first="David" last="Wallon">David Wallon</name><affiliation wicri:level="3"><nlm:aff id="A32">INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><affiliation wicri:level="1"><nlm:aff id="A57">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Kehoe, Pat" sort="Kehoe, Pat" uniqKey="Kehoe P" first="Pat" last="Kehoe">Pat Kehoe</name><affiliation wicri:level="1"><nlm:aff id="A57">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="4"><nlm:aff id="A58">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation><nlm:aff id="A59">Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK</nlm:aff><wicri:noCountry code="subfield">Cardiff UK</wicri:noCountry></affiliation></author><author><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><affiliation wicri:level="4"><nlm:aff id="A58">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A60">Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 1TN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 1TN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation wicri:level="4"><nlm:aff id="A61">Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A62">Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lle, Alberti" sort="Lle, Alberti" uniqKey="Lle A" first="Alberti" last="Lle">Alberti Lle</name><affiliation wicri:level="4"><nlm:aff id="A61">Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A62">Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bayer, Anthony" sort="Bayer, Anthony" uniqKey="Bayer A" first="Anthony" last="Bayer">Anthony Bayer</name><affiliation><nlm:aff id="A59">Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK</nlm:aff><wicri:noCountry code="subfield">Cardiff UK</wicri:noCountry></affiliation></author><author><name sortKey="Tsuang, Debby W" sort="Tsuang, Debby W" uniqKey="Tsuang D" first="Debby W" last="Tsuang">Debby W. Tsuang</name><affiliation wicri:level="4"><nlm:aff id="A63">Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:aff id="A65">Aristotle University of Thessaloniki, Despere 3, Thessaloniki, 54621, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Aristotle University of Thessaloniki, Despere 3, Thessaloniki, 54621</wicri:regionArea><wicri:noRegion>54621</wicri:noRegion></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation wicri:level="3"><nlm:aff id="A66">Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation wicri:level="3"><nlm:aff id="A66">Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Proitsi, Petra" sort="Proitsi, Petra" uniqKey="Proitsi P" first="Petra" last="Proitsi">Petra Proitsi</name><affiliation wicri:level="3"><nlm:aff id="A43">King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill</wicri:orgArea></affiliation></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><affiliation wicri:level="3"><nlm:aff id="A67">MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation wicri:level="1"><nlm:aff id="A68">Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological and Psychiatric Sciences, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Florentino Sanchez" sort="Garcia, Florentino Sanchez" uniqKey="Garcia F" first="Florentino Sanchez" last="Garcia">Florentino Sanchez Garcia</name><affiliation wicri:level="1"><nlm:aff id="A70">Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Nick" sort="Fox, Nick" uniqKey="Fox N" first="Nick" last="Fox">Nick Fox</name><affiliation wicri:level="3"><nlm:aff id="A71">Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="3"><nlm:aff id="A72">Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Naranjo, Maria Candida Deniz" sort="Naranjo, Maria Candida Deniz" uniqKey="Naranjo M" first="Maria Candida Deniz" last="Naranjo">Maria Candida Deniz Naranjo</name><affiliation wicri:level="1"><nlm:aff id="A70">Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author><author><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name><affiliation wicri:level="1"><nlm:aff id="A131">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Bosco, Paola" sort="Bosco, Paola" uniqKey="Bosco P" first="Paola" last="Bosco">Paola Bosco</name><affiliation wicri:level="1"><nlm:aff id="A73">IRCCS Associazione Oasi Maria SS, Troina, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Associazione Oasi Maria SS, Troina</wicri:regionArea><wicri:noRegion>Troina</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="4"><nlm:aff id="A74">Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><affiliation wicri:level="4"><nlm:aff id="A75">Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="3"><nlm:aff id="A76">University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation wicri:level="4"><nlm:aff id="A77">Neurological Clinic, University of Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Clinic, University of Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation wicri:level="1"><nlm:aff id="A78">Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:aff id="A79">Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name><affiliation wicri:level="1"><nlm:aff id="A80">Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation wicri:level="3"><nlm:aff id="A81">Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation><nlm:aff id="A82">Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.)</nlm:aff><wicri:noCountry code="subfield">Germany (H.H.)</wicri:noCountry></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation wicri:level="1"><nlm:aff id="A83">Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG)</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo (FG)</wicri:noRegion></affiliation></author><author><name sortKey="Bullido, Maria" sort="Bullido, Maria" uniqKey="Bullido M" first="Maria" last="Bullido">Maria Bullido</name><affiliation wicri:level="1"><nlm:aff id="A84">Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A85">Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A86">Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation wicri:level="1"><nlm:aff id="A87">Departement of Geriatrics,Center for Aging Brain, University of Bari, Bari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Departement of Geriatrics,Center for Aging Brain, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><affiliation wicri:level="1"><nlm:aff id="A88">Department of Neuroscience-University of Parma, Parma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience-University of Parma, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A89">Center for Cognitive Disorders AUSL, Parma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Cognitive Disorders AUSL, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation wicri:level="1"><nlm:aff id="A68">Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological and Psychiatric Sciences, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Gilbert, John R" sort="Gilbert, John R" uniqKey="Gilbert J" first="John R" last="Gilbert">John R. Gilbert</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A90">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL 33124</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name><affiliation><nlm:aff id="A91">Dept. Of Psychiatry, University Hospital, Saarland</nlm:aff><wicri:noCountry code="subfield">Saarland</wicri:noCountry></affiliation></author><author><name sortKey="Jessen, Frank" sort="Jessen, Frank" uniqKey="Jessen F" first="Frank" last="Jessen">Frank Jessen</name><affiliation wicri:level="3"><nlm:aff id="A81">Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="4"><nlm:aff id="A133">Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany and German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany and German Center for Neurodegenerative Diseases (DZNE, Munich), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation wicri:level="4"><nlm:aff id="A92">Dept. of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Public Health/Geriatrics, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:aff id="A93">Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><affiliation><nlm:aff id="A91">Dept. Of Psychiatry, University Hospital, Saarland</nlm:aff><wicri:noCountry code="subfield">Saarland</wicri:noCountry></affiliation></author><author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M" last="Carrasquillo">Minerva M. Carrasquillo</name><affiliation><nlm:aff id="A94">Department of Neuroscience, Mayo Clinic, Jacksonville Florida 32224</nlm:aff><wicri:noCountry code="subfield">Jacksonville Florida 32224</wicri:noCountry></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation wicri:level="4"><nlm:aff id="A92">Dept. of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Public Health/Geriatrics, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name><affiliation wicri:level="4"><nlm:aff id="A95">National Alzheimer's Coordinating Center, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Alzheimer's Coordinating Center, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Alavarez, Victoria" sort="Alavarez, Victoria" uniqKey="Alavarez V" first="Victoria" last="Alavarez">Victoria Alavarez</name><affiliation wicri:level="1"><nlm:aff id="A96">Genetica molecular-Huca-Oviedo, Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica molecular-Huca-Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Zou, Fanggeng" sort="Zou, Fanggeng" uniqKey="Zou F" first="Fanggeng" last="Zou">Fanggeng Zou</name><affiliation><nlm:aff id="A94">Department of Neuroscience, Mayo Clinic, Jacksonville Florida 32224</nlm:aff><wicri:noCountry code="subfield">Jacksonville Florida 32224</wicri:noCountry></affiliation></author><author><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G" last="Younkin">Steven G. Younkin</name><affiliation><nlm:aff id="A94">Department of Neuroscience, Mayo Clinic, Jacksonville Florida 32224</nlm:aff><wicri:noCountry code="subfield">Jacksonville Florida 32224</wicri:noCountry></affiliation></author><author><name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name><affiliation wicri:level="1"><nlm:aff id="A96">Genetica molecular-Huca-Oviedo, Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica molecular-Huca-Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L" last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation wicri:level="1"><nlm:aff id="A97">Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Faber, Kelley M" sort="Faber, Kelley M" uniqKey="Faber K" first="Kelley M" last="Faber">Kelley M. Faber</name><affiliation wicri:level="2"><nlm:aff id="A98">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V" last="Jonsson">Palmi V. Jonsson</name><affiliation wicri:level="1"><nlm:aff id="A99">Landspitali University Hospital, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Landspitali University Hospital, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation wicri:level="1"><nlm:aff id="A97">Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C" last="O'Donovan">Michael C. O'Donovan</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B" last="Cantwell">Laura B. Cantwell</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="A100">Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, 70211 Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A101">Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio</wicri:regionArea><wicri:noRegion>FIN-70211 Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><affiliation wicri:level="2"><nlm:aff id="A102">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A104">Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><affiliation wicri:level="3"><nlm:aff id="A67">MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation wicri:level="2"><nlm:aff id="A106">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name><affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A106">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation wicri:level="2"><nlm:aff id="A107">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><affiliation wicri:level="3"><nlm:aff id="A108">Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation><nlm:aff id="A109">Dept Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, S-14186 Stockholm</nlm:aff><wicri:noCountry code="subfield">S-14186 Stockholm</wicri:noCountry></affiliation></author><author><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><affiliation wicri:level="1"><nlm:aff id="A110">Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="De Bruijn, Renee Fag" sort="De Bruijn, Renee Fag" uniqKey="De Bruijn R" first="Renee Fag" last="De Bruijn">Renee Fag De Bruijn</name><affiliation wicri:level="1"><nlm:aff id="A111">Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE</wicri:regionArea><wicri:noRegion>3015 CE</wicri:noRegion></affiliation></author><author><name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name><affiliation wicri:level="1"><nlm:aff id="A36">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast</wicri:regionArea><wicri:noRegion>Queen's University Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name><affiliation wicri:level="4"><nlm:aff id="A112">Department of Pathology, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation wicri:level="1"><nlm:aff id="A47">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A48">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:aff id="A113">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:aff id="A114">CRicm-UMRS975, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CRicm-UMRS975, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A115">AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital de la Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><affiliation wicri:level="4"><nlm:aff id="A51">Institute of Genetics, Queen's Medical Centre, University of Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics, Queen's Medical Centre, University of Nottingham</wicri:regionArea><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName><orgName type="university">Université de Nottingham</orgName></affiliation></author><author><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M" last="Foroud">Tatiana M. Foroud</name><affiliation wicri:level="2"><nlm:aff id="A98">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN 46202</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name><affiliation wicri:level="4"><nlm:aff id="A116">Department of Epidemiology, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="3"><nlm:aff id="A32">INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name><affiliation wicri:level="3"><nlm:aff id="A43">King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill</wicri:orgArea></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><affiliation wicri:level="2"><nlm:aff id="A117">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><nlm:aff id="A38">INSERM U888, Hôpital La Colombière, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U888, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation></author><author><name sortKey="Kauwe, John Sk" sort="Kauwe, John Sk" uniqKey="Kauwe J" first="John Sk" last="Kauwe">John Sk Kauwe</name><affiliation wicri:level="4"><nlm:aff id="A46">Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="2"><nlm:aff id="A118">Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A119">Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><affiliation><nlm:aff id="A120">Department of Psychiatry, University Hospital, Saarland</nlm:aff><wicri:noCountry code="subfield">Saarland</wicri:noCountry></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><affiliation wicri:level="1"><nlm:aff id="A22">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029</wicri:regionArea><wicri:noRegion>8029</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A121">Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona 8029, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona 8029</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation wicri:level="1"><nlm:aff id="A100">Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, 70211 Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A101">Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio</wicri:regionArea><wicri:noRegion>FIN-70211 Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><affiliation wicri:level="1"><nlm:aff id="A132">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research and Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research and Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</wicri:regionArea><wicri:noRegion>Instituto de Salud Carlos III</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A122">Department of Neurology, Medical University of Graz, Graz 8010, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Graz, Graz 8010</wicri:regionArea><wicri:noRegion>Graz 8010</wicri:noRegion></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation wicri:level="4"><nlm:aff id="A123">Department of Psychiatry, University of Munich, Munich and University of Halle, Halle, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Munich, Munich and University of Halle, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation wicri:level="3"><nlm:aff id="A44">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A124">Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><affiliation wicri:level="1"><nlm:aff id="A23">Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University Department of Neurology, Columbia University, New York, NY, 10027</wicri:regionArea><wicri:noRegion>10027</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:aff id="A125">Inserm U708, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U708, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><wicri:noRegion>33076, Bordeaux</wicri:noRegion><wicri:noRegion>33076, Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="A16">Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE</wicri:regionArea><wicri:noRegion>3015 CE</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A17">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation wicri:level="3"><nlm:aff id="A126">Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><affiliation wicri:level="1"><nlm:aff id="A127">Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, KIADRC, Novum floor 5, S14186 Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, KIADRC, Novum floor 5, S14186 Stockholm</wicri:regionArea><wicri:noRegion>S14186 Stockholm</wicri:noRegion></affiliation><affiliation><nlm:aff id="A109">Dept Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, S-14186 Stockholm</nlm:aff><wicri:noCountry code="subfield">S-14186 Stockholm</wicri:noCountry></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><nlm:aff id="A10">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212</wicri:regionArea><wicri:noRegion>37212</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A128">Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="3"><nlm:aff id="A18">Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A19">Fondation Jean Dausset- CEPH, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A129">McGill University and Génome Québec Innovation Centre, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University and Génome Québec Innovation Centre, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation wicri:level="1"><nlm:aff id="A6">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33124</wicri:regionArea><wicri:noRegion>33124</wicri:noRegion></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:aff id="A107">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218</wicri:regionArea><wicri:noRegion>02218</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA, 02215</wicri:regionArea><wicri:noRegion>02215</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118</wicri:regionArea><wicri:noRegion>02118</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A103">Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A130">Department of Neurology, Boston University School of Medicine, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A37">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE the Netherlands</nlm:aff><wicri:noCountry code="subfield">3015 CE the Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Van Broekhoven, Christine" sort="Van Broekhoven, Christine" uniqKey="Van Broekhoven C" first="Christine" last="Van Broekhoven">Christine Van Broekhoven</name><affiliation wicri:level="1"><nlm:aff id="A47">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A48">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name><affiliation wicri:level="3"><nlm:aff id="A26">Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D" last="Schellenberg">Gerard D. Schellenberg</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104</wicri:regionArea><wicri:noRegion>19104</wicri:noRegion></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="A130">Department of Neurology, Boston University School of Medicine, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="A2">Inserm U744, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille, 59000</wicri:regionArea><wicri:noRegion>59000</wicri:noRegion><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Université Lille 2, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">Institut Pasteur de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille, 59000</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation></author><author><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author><author><name sortKey="Holmans, Peter A" sort="Holmans, Peter A" uniqKey="Holmans P" first="Peter A" last="Holmans">Peter A. Holmans</name><affiliation wicri:level="1"><nlm:aff id="A1">Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University</wicri:regionArea><wicri:noRegion>Cardiff University</wicri:noRegion></affiliation></author></analytic><series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title><idno type="ISSN">1552-5260</idno><idno type="eISSN">1552-5279</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Late–onset Alzheimer's disease (AD) is heritable with 20 genes showing genome wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease we extended these genetic data in a pathway analysis.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain.</p></sec><sec id="S3"><title>Results</title><p id="P3">ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (p = 3.27×10<sup>-12</sup> after multiple testing correction for pathways), regulation of endocytosis (p = 1.31×10<sup>-11</sup>), cholesterol transport (p = 2.96 × 10<sup>-9</sup>) and proteasome-ubiquitin activity (p = 1.34×10<sup>-6</sup>). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected p 0.002 – 0.05).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The immune response, regulation of endocytosis, cholesterol transport and protein ubiquitination represent prime targets for AD therapeutics.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Irlande (pays)</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Aquitaine</li><li>Arizona</li><li>Bavière</li><li>Californie</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Cologne</li><li>District de Haute-Bavière</li><li>East Middle Sweden</li><li>Floride</li><li>Grand Londres</li><li>Haute-Normandie</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Illinois</li><li>Indiana</li><li>Languedoc-Roussillon</li><li>Latium</li><li>Lombardie</li><li>Maryland</li><li>Massachusetts</li><li>Missouri (État)</li><li>Nord-Pas-de-Calais</li><li>Nottinghamshire</li><li>Nouvelle-Aquitaine</li><li>Occitanie (région administrative)</li><li>Ontario</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Province d'Anvers</li><li>Québec</li><li>Rhénanie-du-Nord-Westphalie</li><li>Région Normandie</li><li>Région flamande</li><li>Svealand</li><li>Tennessee</li><li>Texas</li><li>Toscane</li><li>Washington (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Anvers</li><li>Barcelone</li><li>Bonn</li><li>Bordeaux</li><li>Cambridge</li><li>Leyde</li><li>Lille</li><li>Londres</li><li>Madrid</li><li>Milan</li><li>Montpellier</li><li>Montréal</li><li>Munich</li><li>Nottingham</li><li>Oxford</li><li>Paris</li><li>Pise</li><li>Pittsburgh</li><li>Rome</li><li>Rouen</li><li>Saint-Louis (Missouri)</li><li>Seattle</li><li>Stockholm</li><li>Toronto</li><li>Uppsala</li><li>Évry (Essonne)</li></settlement><orgName><li>Université Lille 2</li><li>Université Louis-et-Maximilien de Munich</li><li>Université Paris-Descartes</li><li>Université autonome de Barcelone</li><li>Université d'Anvers</li><li>Université d'Oxford</li><li>Université d'Uppsala</li><li>Université de Cambridge</li><li>Université de Nottingham</li><li>Université de Pise</li><li>Université de Pittsburgh</li><li>Université de Toronto</li><li>Université de Washington</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><noCountry><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><name sortKey="Bayer, Anthony" sort="Bayer, Anthony" uniqKey="Bayer A" first="Anthony" last="Bayer">Anthony Bayer</name><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M" last="Carrasquillo">Minerva M. Carrasquillo</name><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G" last="Younkin">Steven G. Younkin</name><name sortKey="Zou, Fanggeng" sort="Zou, Fanggeng" uniqKey="Zou F" first="Fanggeng" last="Zou">Fanggeng Zou</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name></noRegion><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name><name sortKey="Fox, Nick" sort="Fox, Nick" uniqKey="Fox N" first="Nick" last="Fox">Nick Fox</name><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><name sortKey="Gerrish, Amy" sort="Gerrish, Amy" uniqKey="Gerrish A" first="Amy" last="Gerrish">Amy Gerrish</name><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><name sortKey="Hollingworth, Paul" sort="Hollingworth, Paul" uniqKey="Hollingworth P" first="Paul" last="Hollingworth">Paul Hollingworth</name><name sortKey="Holmans, Peter A" sort="Holmans, Peter A" uniqKey="Holmans P" first="Peter A" last="Holmans">Peter A. Holmans</name><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><name sortKey="Johnston, Janet A" sort="Johnston, Janet A" uniqKey="Johnston J" first="Janet A" last="Johnston">Janet A. Johnston</name><name sortKey="Jones, Nicola" sort="Jones, Nicola" uniqKey="Jones N" first="Nicola" last="Jones">Nicola Jones</name><name sortKey="Kauwe, John Sk" sort="Kauwe, John Sk" uniqKey="Kauwe J" first="John Sk" last="Kauwe">John Sk Kauwe</name><name sortKey="Kehoe, Pat" sort="Kehoe, Pat" uniqKey="Kehoe P" first="Pat" last="Kehoe">Pat Kehoe</name><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><name sortKey="Mcguinness, Bernadette" sort="Mcguinness, Bernadette" uniqKey="Mcguinness B" first="Bernadette" last="Mcguinness">Bernadette Mcguinness</name><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C" last="O'Donovan">Michael C. O'Donovan</name><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name><name sortKey="Proitsi, Petra" sort="Proitsi, Petra" uniqKey="Proitsi P" first="Petra" last="Proitsi">Petra Proitsi</name><name sortKey="Richards, Alexander" sort="Richards, Alexander" uniqKey="Richards A" first="Alexander" last="Richards">Alexander Richards</name><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name><name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name><name sortKey="Stone, Timothy" sort="Stone, Timothy" uniqKey="Stone T" first="Timothy" last="Stone">Timothy Stone</name><name sortKey="Thomas, Charlene" sort="Thomas, Charlene" uniqKey="Thomas C" first="Charlene" last="Thomas">Charlene Thomas</name><name sortKey="Todd, Stephen" sort="Todd, Stephen" uniqKey="Todd S" first="Stephen" last="Todd">Stephen Todd</name><name sortKey="Vedernikov, Alexey" sort="Vedernikov, Alexey" uniqKey="Vedernikov A" first="Alexey" last="Vedernikov">Alexey Vedernikov</name><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name></country><country name="France"><noRegion><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name></noRegion><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><name sortKey="Bihoreau, Marie Therese" sort="Bihoreau, Marie Therese" uniqKey="Bihoreau M" first="Marie-Thérèse" last="Bihoreau">Marie-Thérèse Bihoreau</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><name sortKey="Letteneur, Luc" sort="Letteneur, Luc" uniqKey="Letteneur L" first="Luc" last="Letteneur">Luc Letteneur</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><name sortKey="Wallon, David" sort="Wallon, David" uniqKey="Wallon D" first="David" last="Wallon">David Wallon</name><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name></country><country name="États-Unis"><noRegion><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name></noRegion><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D" last="Buxbaum">Joseph D. Buxbaum</name><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D" last="Buxbaum">Joseph D. Buxbaum</name><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D" last="Buxbaum">Joseph D. Buxbaum</name><name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B" last="Cantwell">Laura B. Cantwell</name><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K" last="Crane">Paul K. Crane</name><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L" last="De Jager">Philip L. De Jager</name><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L" last="De Jager">Philip L. De Jager</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><name sortKey="Faber, Kelley M" sort="Faber, Kelley M" uniqKey="Faber K" first="Kelley M" last="Faber">Kelley M. Faber</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L" last="Fitzpatrick">Annette L. Fitzpatrick</name><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L" last="Fitzpatrick">Annette L. Fitzpatrick</name><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M" last="Foroud">Tatiana M. Foroud</name><name sortKey="Gilbert, John R" sort="Gilbert, John R" uniqKey="Gilbert J" first="John R" last="Gilbert">John R. Gilbert</name><name sortKey="Gilbert, John R" sort="Gilbert, John R" uniqKey="Gilbert J" first="John R" last="Gilbert">John R. Gilbert</name><name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M" last="Goate">Alison M. Goate</name><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L" last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><name sortKey="Huentelman, Matthew J" sort="Huentelman, Matthew J" uniqKey="Huentelman M" first="Matthew J" last="Huentelman">Matthew J. Huentelman</name><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name><name sortKey="Kunkle, Brian" sort="Kunkle, Brian" uniqKey="Kunkle B" first="Brian" last="Kunkle">Brian Kunkle</name><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><name sortKey="Lin, Chiao Feng" sort="Lin, Chiao Feng" uniqKey="Lin C" first="Chiao-Feng" last="Lin">Chiao-Feng Lin</name><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><name sortKey="Myers, Amanda J" sort="Myers, Amanda J" uniqKey="Myers A" first="Amanda J" last="Myers">Amanda J. Myers</name><name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C" last="Naj">Adam C. Naj</name><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D" last="Schellenberg">Gerard D. Schellenberg</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Thornton Wells, Tricia A" sort="Thornton Wells, Tricia A" uniqKey="Thornton Wells T" first="Tricia A" last="Thornton-Wells">Tricia A. Thornton-Wells</name><name sortKey="Tsuang, Debby W" sort="Tsuang, Debby W" uniqKey="Tsuang D" first="Debby W" last="Tsuang">Debby W. Tsuang</name><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N" last="Vardarajan">Badri N. Vardarajan</name><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N" last="Vardarajan">Badri N. Vardarajan</name><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name></country><country name="Pays-Bas"><noRegion><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A" last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name></noRegion><name sortKey="De Bruijn, Renee Fag" sort="De Bruijn, Renee Fag" uniqKey="De Bruijn R" first="Renee Fag" last="De Bruijn">Renee Fag De Bruijn</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name></country><country name="Suisse"><noRegion><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name></noRegion></country><country name="Islande"><noRegion><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name></noRegion><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V" last="Jonsson">Palmi V. Jonsson</name><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name></country><country name="Autriche"><noRegion><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name></noRegion><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name></country><country name="Espagne"><noRegion><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name></noRegion><name sortKey="Alavarez, Victoria" sort="Alavarez, Victoria" uniqKey="Alavarez V" first="Victoria" last="Alavarez">Victoria Alavarez</name><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><name sortKey="Bullido, Maria" sort="Bullido, Maria" uniqKey="Bullido M" first="Maria" last="Bullido">Maria Bullido</name><name sortKey="Bullido, Maria" sort="Bullido, Maria" uniqKey="Bullido M" first="Maria" last="Bullido">Maria Bullido</name><name sortKey="Bullido, Maria" sort="Bullido, Maria" uniqKey="Bullido M" first="Maria" last="Bullido">Maria Bullido</name><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name><name sortKey="Garcia, Florentino Sanchez" sort="Garcia, Florentino Sanchez" uniqKey="Garcia F" first="Florentino Sanchez" last="Garcia">Florentino Sanchez Garcia</name><name sortKey="Lle, Alberti" sort="Lle, Alberti" uniqKey="Lle A" first="Alberti" last="Lle">Alberti Lle</name><name sortKey="Lle, Alberti" sort="Lle, Alberti" uniqKey="Lle A" first="Alberti" last="Lle">Alberti Lle</name><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><name sortKey="Naranjo, Maria Candida Deniz" sort="Naranjo, Maria Candida Deniz" uniqKey="Naranjo M" first="Maria Candida Deniz" last="Naranjo">Maria Candida Deniz Naranjo</name><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name><name sortKey="Tarraga, Lluis" sort="Tarraga, Lluis" uniqKey="Tarraga L" first="Lluís" last="Tárraga">Lluís Tárraga</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name></region><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><name sortKey="Jessen, Frank" sort="Jessen, Frank" uniqKey="Jessen F" first="Frank" last="Jessen">Frank Jessen</name><name sortKey="Kornhuber, Johanes" sort="Kornhuber, Johanes" uniqKey="Kornhuber J" first="Johanes" last="Kornhuber">Johanes Kornhuber</name><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name></country><country name="Belgique"><noRegion><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name></noRegion><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><name sortKey="Van Broekhoven, Christine" sort="Van Broekhoven, Christine" uniqKey="Van Broekhoven C" first="Christine" last="Van Broekhoven">Christine Van Broekhoven</name><name sortKey="Van Broekhoven, Christine" sort="Van Broekhoven, Christine" uniqKey="Van Broekhoven C" first="Christine" last="Van Broekhoven">Christine Van Broekhoven</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Keller, Lina" sort="Keller, Lina" uniqKey="Keller L" first="Lina" last="Keller">Lina Keller</name></region><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name></country><country name="Canada"><region name="Ontario"><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name></region><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name></country><country name="Grèce"><noRegion><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name></noRegion></country><country name="Italie"><region name="Latium"><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name></region><name sortKey="Bosco, Paola" sort="Bosco, Paola" uniqKey="Bosco P" first="Paola" last="Bosco">Paola Bosco</name><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name></country><country name="Finlande"><noRegion><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name></noRegion><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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